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Adverse Events

Incidence of serious adverse events in all CIMZIA clinical trials (per 100 patient-years)1

In completed and ongoing clinical studies (CIMZIA, n=5118)*:
  • Tuberculosis: CIMZIA, 0.61 vs placebo, 0

In all clinical trials (CIMZIA, n=4650; placebo, n=1319)*:
  • Malignancies: CIMZIA, 0.5 (0.4, 0.7) vs placebo, 0.6 (0.1, 1.7)

In CIMZIA RA clinical trials (CIMZIA, n=2367)*:
  • A total of 3 cases of lymphoma were observed

Treatment-Emergent Adverse Reactions Reported by ≥3% of Patients Treated with CIMZIA Dosed Every Other Week During the Placebo-Controlled Period of Rheumatoid Arthritis Studies with Concomitant Methotrexate1

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  • In RA clinical trials, 5% of patients discontinued taking CIMZIA therapy due to adverse events vs 2.5% for placebo
  • Patients receiving CIMZIA 400 mg as monotherapy every 4 weeks in RA-controlled clinical trials had similar adverse reactions to those patients receiving CIMZIA 200 mg every 2 weeks
*Including other investigational uses.
Numbers in parentheses represent a 95% confidence interval.



Reference:
1. CIMZIA [prescribing information]. Smyrna, GA: UCB, Inc.; 2009.
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